What is the 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide?

4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide is , while it's Molecular Formula is C 22 H 17 Cl 2 F 6 N 3 O 3 . Fluralaner is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. Fluralaner belongs to a new class of compounds, the isoxazolines. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control. The long duration of activity offers a more convenient treatment over monthly flea and tick control treatments with a potential compliance advantage, reducing the risk of vector-transmitted diseases.

What is the CAS number for 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide?

The CAS number of 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide is 864731-61-3.

What is 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide (864731-61-3) used for?

Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.

What is the 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide?

4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide is , while it's Molecular Formula is C 22 H 17 Cl 2 F 6 N 3 O 3 . Fluralaner is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. Fluralaner belongs to a new class of compounds, the isoxazolines. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control. The long duration of activity offers a more convenient treatment over monthly flea and tick control treatments with a potential compliance advantage, reducing the risk of vector-transmitted diseases.

What is the CAS number for 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide?

The CAS number of 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide is 864731-61-3.

What is 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide (864731-61-3) used for?

Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.

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864731-61-3

Product Name：fluralaner
Molecular Formula：
Purity：99%
Molecular Weight：556.292

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Product Details

Factory Supply fluralaner 864731-61-3 for Export at Lowest Price

Molecular Formula:C₂₂H₁₇Cl₂F₆N₃O₃
Molecular Weight:556.292
PKA:12.50±0.46(Predicted)
Density:1.51±0.1 g/cm3(Predicted)

Fluralaner(Cas 864731-61-3) Usage

Description	Fluralaner, also known as AH252723, is a systemic insecticide and acaricide that is administered orally.
Uses	The US Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and l-glutamate-gated chloride channels (GluCls).

InChI:InChI=1S/C22H17Cl2F6N3O3/c1-11-4-12(2-3-16(11)19(35)31-9-18(34)32-10-21(25,26)27)17-8-20(36-33-17,22(28,29)30)13-5-14(23)7-15(24)6-13/h2-7H,8-10H2,1H3,(H,31,35)(H,32,34)

864731-61-3 Relevant articles

Synthetic method of fluralana

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, (2022/04/15)

According to the method, 2-methyl-5-brom...

PROCESS FOR PREPARATION OF ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND

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, (2022/03/14)

The invention relates to process for the...

PROCESS FOR PREPARING FLURALANER

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Paragraph 0074-0082, (2021/06/26)

The invention relates to an improved pro...

Fluorine thramine intermediate and method for preparing flumbine by using same

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Paragraph 0173-0175; 0182-0189, (2021/12/07)

The invention discloses a fluororesonide...

864731-61-3 Process route

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: C₁₃H₁₃ClF₃N₃O₃

: 864731-61-3
A₁₄₄₃

Conditions

Conditions	Yield
With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;	92.1%
With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃;	91.8%
for 3h;	83%

: 2-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methylbenzoyl]amino]acetic acid

: 753-90-2
trifluoroethylamine

: 864731-61-3
A₁₄₄₃

Conditions

Conditions	Yield
2-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methylbenzoyl]amino]acetic acid; trifluoroethylamine; With dmap; In dichloromethane; at 20 - 25 ℃; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Reagent/catalyst;	75.5%
2-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methylbenzoyl]amino]acetic acid; With N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.25h; trifluoroethylamine; With dmap; In dichloromethane; at 20 ℃; for 2h;

864731-61-3 Upstream products

753-90-2
trifluoroethylamine
201230-82-2
carbon monoxide
359821-38-8
2-ammonia-N-(2,2,2-trifluoroethyl)acetamide
864725-62-2
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

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