19356-17-3

  • Product Name：calcidiol
  • Molecular Formula：C27H44O2
  • Purity：99%
  • Molecular Weight：400.645
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Product Details

Chinese Manufacturer Supply Top Purity calcidiol 19356-17-3 with Safe Delivery

  • Molecular Formula:C27H44O2
  • Molecular Weight:400.645
  • Vapor Pressure:2.07E-13mmHg at 25°C 
  • Melting Point:74-76oC 
  • Boiling Point:529.2 °C at 760 mmHg 
  • PKA:14.74±0.20(Predicted) 
  • Flash Point:221.4 °C 
  • PSA：40.46000 
  • Density:1.01 g/cm3 
  • LogP:6.73390 

CALCIFEDIOL(Cas 19356-17-3) Usage

Description

Calcifediol (synonym 25-Hydroxyvitamin D3) is a vitamin D analog and the major metabolite of vitamin D3 (Cholecalciferol) in the liver. Its main function is the regulation of calcium and phosphorus, which is necessary for strong bones. It is used to treat patients with serious kidney diseases to decrease the parathyroid hormone (PTH) level. It is used to treat rickets and osteomalacia, both in azotemic and non-azotemic patient. Calcifediol is sold under RAYALDEE? to treat secondary hyperparathyroidism associated with vitamin D insufficiency in stage 3-4 chronic kidney disease.

Uses

Calcidiol is the precursor to vitamin D3, a steroid hormone that helps regulate calcium and phosphorus levels in the body, mineralizes bones, and assimilates vitamin A. Calcidiol is fat-soluble and helps with bone and teeth growth and development. It can be used as a stable isotope internal standard for data interpretation in specific biological samples by mass spectrometry.

InChI:InChI=1/C27H44O2.H2O/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29;/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3;1H2/b21-11+,22-12-;/t20-,23+,24-,25+,27-;/m1./s1

19356-17-3 Relevant articles

Oral calcidiol is a good form of vitamin D supplementation

Piergianni Biondi, Jessica Pepe, Federica Biamonte, Marco Occhiuto, Martina Parisi, Chiara Demofonti, Valeria Baffa, Salvatore Minisola, and Cristiana Cipriani

, Clin Cases Miner Bone Metab. 2017 May-Aug; 14(2): 207–208.

Advantages of the use of calcidiol derive from the pharmacokinetic properties and are related to the possibility of use in patients with liver disease, obese patients, patients with intestinal malabsorption, secondary hyperparathyroidism associated with chronic kidney disease as well as to avoid any possible toxic effect when high doses are used.

Vitamin D3 and calcidiol are not equipotent

Cristina Navarro-Valverde a, Manuel Sosa-Henríquez b, Maria Rosa Alhambra-Expósito c, José Manuel Quesada-Gómez c

, The Journal of Steroid Biochemistry and Molecular Biology Volume 164, November 2016, Pages 205-208

In Spain, the use of calcidiol (25(OH)D3) at the same dose than Vitamin D3 is the most extended prescription, notwithstanding the available evidence stating that they are not equipotent. This may lead to over-dosage.

Isolation and identification of 2α,25-dihydroxyvitamin D3, a new metabolite from Pseudonocardia autotrophica 100U-19 cells incubated with Vitamin D3

Takeda, Koji,Kominato, Kaichiro,Sugita, Atsuko,Iwasaki, Yukiko,Shimazaki, Mika,Shimizu, Masato

, p. 736 - 744 (2006)

Pseudonocardia autotrophica converted Vi...

19356-17-3 Process route

2<sup>5</sup>-Hydroxycholecalciferol
19356-17-3,36149-00-5,73809-05-9,142864-49-1

25-Hydroxycholecalciferol

Conditions
Conditions Yield
durch in vivo-Metabol. von Cholecalciferol (I);
 
Metabolit von Vitamin D3 in the chich;
 
 
  
vitamin D<sub>3</sub>
67-97-0

vitamin D3

2alpha,25-Dihydroxyvitamin D<sub>3</sub>

2alpha,25-Dihydroxyvitamin D3

calcitriol
32222-06-3

calcitriol

calcidiol
19356-17-3

calcidiol

Conditions
Conditions Yield
With Pseudonocardia autotrophica 100U-19 cells; In ethanol; at 30 ℃; for 72h;
35 mg

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