717824-30-1
- Product Name:Vidofludimus
- Molecular Formula:C20H18FNO4
- Purity:99%
- Molecular Weight:355.366
Product Details
Chinese Factory Supply High Purity Vidofludimus 717824-30-1 at Lowest Price
- Molecular Formula:C20H18FNO4
- Molecular Weight:355.366
- Boiling Point:567.5±50.0 °C(Predicted)
- PKA:4?+-.0.20(Predicted)
- PSA:79.12000
- Density:1.354±0.06 g/cm3(Predicted)
- LogP:4.65440
Vidofludimus(Cas 717824-30-1) Usage
Description |
Vidofludimus is an orally bioavailable inhibitor of dihydroorotate dehydrogenase (DHODH), with potential anti-inflammatory, immunomodulating and anti-viral activities. Upon administration, vidofludimus specifically targets, binds to and prevents the activation of DHODH. This prevents the fourth enzymatic step in de novo pyrimidine synthesis, leading to inhibition of transcriptional elongation, cell cycle arrest, and apoptosis in activated lymphocytes. |
Uses |
Vidofludimus is a novel, small molecule agent from the class of DMARDs (disease modifying anti-rheumatic drug) for the therapy of autoimmune diseases such as rheumatoid arthritis or multiple sclerosis. Through highly selective inhibition of pyrimidine biosynthesis, it controls the growth of rapidly proliferating cells, especially of lymphocytes, which are important for the immune response. |
InChI:InChI=1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25)
717824-30-1 Relevant articles
DIHYDROOROTATE-DEHYDROGENASEE INHIBITORS AS VIROSTATIC COMPOUNDS
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, (2022/01/23)
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SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors
Leban, Johann,Kralik, Martin,Mies, Jan,Gassen, Michael,Tentschert, Karin,Baumgartner, Roland
, p. 4854 - 4857 (2007/10/03)
Novel DHODH inhibitors were developed ba...
Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
-
, (2008/06/13)
The present invention relates to novel c...
717824-30-1 Process route
- 867287-99-8
3-fluoro-3'-methoxybiphenyl-4-amine
- 3205-94-5
1-cyclopentene-1,2-dicarboxylic anhydride
- 717824-30-1
2-({3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl}carbamoyl)cyclopent-1-ene-1-carboxylic acid
Conditions | Yield |
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- 717824-30-1
2-({3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl}carbamoyl)cyclopent-1-ene-1-carboxylic acid
Conditions | Yield |
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717824-30-1 Upstream products
-
867287-99-8
3-fluoro-3'-methoxybiphenyl-4-amine
-
3205-94-5
1-cyclopentene-1,2-dicarboxylic anhydride
717824-30-1 Downstream products
-
719301-50-5
methyl 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-ene-1-carboxylate
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