717824-30-1

  • Product Name：Vidofludimus
  • Molecular Formula：C20H18FNO4
  • Purity：99%
  • Molecular Weight：355.366
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Product Details

Chinese Factory Supply High Purity Vidofludimus 717824-30-1 at Lowest Price

  • Molecular Formula:C20H18FNO4
  • Molecular Weight:355.366
  • Boiling Point:567.5±50.0 °C(Predicted) 
  • PKA:4?+-.0.20(Predicted) 
  • PSA：79.12000 
  • Density:1.354±0.06 g/cm3(Predicted) 
  • LogP:4.65440 

Vidofludimus(Cas 717824-30-1) Usage

Description

 Vidofludimus is an orally bioavailable inhibitor of dihydroorotate dehydrogenase (DHODH), with potential anti-inflammatory, immunomodulating and anti-viral activities. Upon administration, vidofludimus specifically targets, binds to and prevents the activation of DHODH. This prevents the fourth enzymatic step in de novo pyrimidine synthesis, leading to inhibition of transcriptional elongation, cell cycle arrest, and apoptosis in activated lymphocytes.

Uses

 Vidofludimus is a novel, small molecule agent from the class of DMARDs (disease modifying anti-rheumatic drug) for the therapy of autoimmune diseases such as rheumatoid arthritis or multiple sclerosis. Through highly selective inhibition of pyrimidine biosynthesis, it controls the growth of rapidly proliferating cells, especially of lymphocytes, which are important for the immune response.

InChI:InChI=1S/C20H18FNO4/c1-26-14-5-2-4-12(10-14)13-8-9-18(17(21)11-13)22-19(23)15-6-3-7-16(15)20(24)25/h2,4-5,8-11H,3,6-7H2,1H3,(H,22,23)(H,24,25)

717824-30-1 Relevant articles

DIHYDROOROTATE-DEHYDROGENASEE INHIBITORS AS VIROSTATIC COMPOUNDS

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, (2022/01/23)

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SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors

Leban, Johann,Kralik, Martin,Mies, Jan,Gassen, Michael,Tentschert, Karin,Baumgartner, Roland

, p. 4854 - 4857 (2007/10/03)

Novel DHODH inhibitors were developed ba...

Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

-

, (2008/06/13)

The present invention relates to novel c...

717824-30-1 Process route

3-fluoro-3'-methoxybiphenyl-4-amine
867287-99-8

3-fluoro-3'-methoxybiphenyl-4-amine

1-cyclopentene-1,2-dicarboxylic anhydride
3205-94-5

1-cyclopentene-1,2-dicarboxylic anhydride

2-({3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl}carbamoyl)cyclopent-1-ene-1-carboxylic acid
717824-30-1

2-({3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl}carbamoyl)cyclopent-1-ene-1-carboxylic acid

Conditions
Conditions Yield
 
  
2-({3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl}carbamoyl)cyclopent-1-ene-1-carboxylic acid
717824-30-1

2-({3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl}carbamoyl)cyclopent-1-ene-1-carboxylic acid

Conditions
Conditions Yield
 
  
 
  

717824-30-1 Upstream products

  • 867287-99-8
    867287-99-8

    3-fluoro-3'-methoxybiphenyl-4-amine

  • 3205-94-5
    3205-94-5

    1-cyclopentene-1,2-dicarboxylic anhydride

717824-30-1 Downstream products

  • 719301-50-5
    719301-50-5

    methyl 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-ene-1-carboxylate

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