843666-40-0
- Product Name：18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid
- Molecular Formula：C22H42 O4
- Purity：99%
- Molecular Weight：370.573
Product Details
Factory Supply Wholesale 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid 843666-40-0 at a Cheap Price
- Molecular Formula:C22H42 O4
- Molecular Weight:370.573
- Melting Point:68 °C
- Boiling Point:470.7±18.0 °C(Predicted)
- PKA:4.78±0.10(Predicted)
- PSA：63.60000
- Density:0.950±0.06 g/cm3(Predicted)
- LogP:6.65430
18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid(Cas 843666-40-0) Usage
|
Description |
18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
|
Uses |
18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid can be used in the synthesis of PROTACs. |
InChI:InChI=1S/C22H42O4/c1-22(2,3)26-21(25)19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20(23)24/h4-19H2,1-3H3,(H,23,24)
843666-40-0 Relevant articles
GLP-1R AND GCGR AGONISTS, FORMULATIONS, AND METHODS OF USE
-
Paragraph 00168-00169, (2021/08/27)
This disclosure relates to the field of ...
Preparation method of long-chain aliphatic dicarboxylic acid mono-tert-butyl ester
-
, (2021/07/09)
The invention provides a method for obta...
Preparation method of long-chain alkyl diacid mono-tert-butyl ester
-
, (2021/06/13)
The invention relates to a preparation m...
Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320
Kjeldsen, Thomas B.,Hubálek, Franti?ek,Tagmose, Tina M.,Pridal, Lone,Refsgaard, Hanne H. F.,Porsgaard, Trine,Gram-Nielsen, Sanne,Hovgaard, Lars,Valore, Henrik,Münzel, Martin,Hj?rringgaard, Claudia U.,Jeppesen, Claus Bekker,Manfè, Valentina,Hoeg-Jensen, Thomas,Ludvigsen, Svend,Nielsen, Peter Kresten,Lautrup-Larsen, Inger,Stidsen, Carsten E.,Wulff, Erik M.,Garibay, Patrick W.,Kodra, János T.,Nishimura, Erica,Madsen, Peter
, p. 616 - 628 (2021/01/13)
Recently, the first basal oral insulin (...
843666-40-0 Process route
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- 871-70-5
octadecanedioic acid
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- 36805-97-7
N,N-dimethylformamide di-tert-butyl acetal
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- 843666-40-0
1,18-octadecanedioic acid mono-tert-butyl ester
| Conditions | Yield |
|---|---|
|
In toluene; at 95 ℃; Inert atmosphere;
|
86% |
|
In toluene; Concentration; Reflux;
|
57.4% |
|
In n-heptane; dichloromethane; toluene;
|
-
-
octadecanedioic acid ditert-butyl ester
-
- 843666-40-0
1,18-octadecanedioic acid mono-tert-butyl ester
| Conditions | Yield |
|---|---|
|
With barium hydroxide octahydrate; In methanol; tert-butyl alcohol; at 28 - 30 ℃; for 20h; Large scale;
|
71% |
843666-40-0 Upstream products
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871-70-5
octadecanedioic acid
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36805-97-7
N,N-dimethylformamide di-tert-butyl acetal
-
45270-18-6
1,18-octadecanedioyl dichloride
-
75-65-0
tert-butyl alcohol
843666-40-0 Downstream products
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843666-34-2
octadecanedioic acid tert-butyl ester-2,5-dioxopyrrolidin-1-yl ester
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1448547-34-9
(S)-1-(aminooxy)-19-carboxy-2,7,16,21-tetraoxo-9,12-dioxa-3,6,15,20-tetraazaoctatriacontan-38-oic acid
Relevant Products
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Malic acidCAS：6915-15-7
-
18-methoxy-18-oxooctadecanoic acidCAS：72849-35-5
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Dimethyl OctadecanedioateCAS：1472-93-1
