1374743-00-6

  • Product Name：Trilaciclib
  • Molecular Formula：
  • Purity：99%
  • Molecular Weight：446.555
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Product Details

Quality Manufacturer Supply Top Purity Trilaciclib 1374743-00-6 at the Lowest Price

  • Molecular Formula:C24H30N8O
  • Molecular Weight:446.555
  • Density:1.46±0.1 g/cm3(Predicted) 

Trilaciclib(Cas 1374743-00-6) Usage

Description

 Trilaciclib is a Kinase Inhibitor. The mechanism of action of trilaciclib is as a Cyclin-dependent Kinase 4 Inhibitor, and Cyclin-dependent Kinase 6 Inhibitor, and Organic Cation Transporter 2 Inhibitor, and Multidrug and Toxin Extrusion Transporter 1 Inhibitor, and Multidrug and Toxin Extrusion Transporter 2 K Inhibitor.

Uses

 Trilaciclib, or G1T28, is a CDK4 and CDK6 inhibitor, indicated to reduce the incidence of chemotherapy induced myelosuppression in patients before topotecan-containing or platinum and etoposide-containing chemotherapy for extensive stage small cell lung cancer. CDK4 and CDK6 inhibitors have been investigated since the mid 1990s for their use in tumorigenesis and chemotherapy. Trilaciclib was first described in the literature in 2016. Trilaciclib was granted FDA approval on 12 February 2021.

InChI:InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)

1374743-00-6 Relevant articles

SYNTHESIS OF N-(HETEROARYL)-PYRROLO[3,2-D]PYRIMIDIN-2-AMINES

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1374743-00-6 Process route

5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine
571189-49-6

5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine

C<sub>15</sub>H<sub>18</sub>N<sub>4</sub>O<sub>3</sub>S

C15H18N4O3S

trilaciclib
1374743-00-6

trilaciclib

Conditions
Conditions Yield
With lithium hexamethyldisilazane; In tetrahydrofuran; Inert atmosphere;
63.7%
tert-butyl [(1-aminocyclohexyl)methyl]carbamate

tert-butyl [(1-aminocyclohexyl)methyl]carbamate

trilaciclib
1374743-00-6

trilaciclib

Conditions
Conditions Yield
Multi-step reaction with 10 steps
1: hydrogen; platinum on activated charcoal
2: hydrogenchloride / water
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 60 h
4: dmap / dichloromethane / 3 h / 20 °C
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h
6: triethylamine / dichloromethane / 3 h / Inert atmosphere
7: triethylsilane; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; N,N-dimethyl-formamide / 14 h / 45 - 50 °C / Inert atmosphere
8: trifluoroacetic acid / dichloromethane / 20 °C
9: Oxone / acetonitrile; water
10: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
With hydrogenchloride; triethylsilane; dmap; Oxone; tetrakis(triphenylphosphine) palladium(0); platinum on activated charcoal; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;
 
Multi-step reaction with 11 steps
1: potassium carbonate / acetonitrile
2: 1,2-dichloro-ethane / Reflux
3: potassium carbonate / ethanol / 20 °C
4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 60 h
5: dmap / dichloromethane / 3 h / 20 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h
7: triethylamine / dichloromethane / 3 h / Inert atmosphere
8: triethylsilane; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; N,N-dimethyl-formamide / 14 h / 45 - 50 °C / Inert atmosphere
9: trifluoroacetic acid / dichloromethane / 20 °C
10: Oxone / acetonitrile; water
11: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
With triethylsilane; dmap; Oxone; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
 
Multi-step reaction with 7 steps
1.1: hydrogen; platinum on activated charcoal
2.1: hydrogenchloride / water
3.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 24 h / 80 - 85 °C
4.1: dmap / dichloromethane / 3 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2.17 h / 20 °C
5.2: 1 h
6.1: Oxone / acetonitrile; water
7.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
With hydrogenchloride; dmap; Oxone; platinum on activated charcoal; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;
 
Multi-step reaction with 7 steps
1.1: hydrogen; platinum on activated charcoal
2.1: hydrogenchloride / water
3.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol
4.1: dmap / dichloromethane / 3 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 2.17 h / 20 °C
5.2: 1 h
6.1: Oxone / acetonitrile; water
7.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
With hydrogenchloride; dmap; Oxone; platinum on activated charcoal; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;
 
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetonitrile
2.1: 1,2-dichloro-ethane / Reflux
3.1: potassium carbonate / ethanol / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 24 h / 80 - 85 °C
5.1: dmap / dichloromethane / 3 h / 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 2.17 h / 20 °C
6.2: 1 h
7.1: Oxone / acetonitrile; water
8.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
With dmap; Oxone; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
 
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetonitrile
2.1: 1,2-dichloro-ethane / Reflux
3.1: potassium carbonate / ethanol / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol
5.1: dmap / dichloromethane / 3 h / 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 2.17 h / 20 °C
6.2: 1 h
7.1: Oxone / acetonitrile; water
8.1: lithium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
With dmap; Oxone; potassium tert-butylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
 

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